Il principio femminile in Pedro Almodóvar. Un percorso di educazione al sentire

Over time in his movies, Pedro Almodóvar not only has explored female sensibility, but has showed that it can be defined, in the latest modernity, as an “avant-garde” in the ability to live feelings and move in the direction of a full expression of the potential of the human being. On the article, at first it’s exposed how the director from La Mancha has showed that the path to the liberation of desire goes through the subversion of roles and structured habits in the dominant culture. Then the audience is invited to follow its female characters in a new continent of feelings.Pedro Almodóvar en sus películas, a lo largo del tiempo, no sólo ha explorado la sensibilidad femenina, sino que ha demostrado que esta última puede definirse, en el Occidente de la última modernidad, como una “vanguardia” en la capacidad de vivir los sentimientos y de moverse hacia una plena expresión de las potencialidades del ser humano. El director manchego primero mostró que el camino para la liberación del deseo pasa por la subversión de los papeles y hábitos estructurados en la cultura dominante. Luego invitó al público a seguir a sus personajes femeninos en un nuevo continente de los sentimientos.Con i suoi film Pedro Almodovar, nel corso del tempo, non solo ha esplorato la sensibilità femminile, ma ha mostrato che quest'ultima può definirsi, nell'Occidente dell'ultima modernità, come una "avanguardia" nella capacità di vivere i sentimenti e di muoversi in direzione di una piena espressione delle potenzialità dell'essere umano. Il regista mancego dapprima ha mostrato che la strada per la liberazione del desiderio passa per la sovversione dei ruoli e delle abitudini strutturate nella cultura dominante. Ha poi invitato il pubblico a seguire i suoi personaggi femminili in un nuovo continente del sentire.   Contributo di Arturo Lando: Insegnare il cinema ad educare al sentire, Conquista del desiderio e autorealizzazione del femminile, I "soggetti eccentrici" e l'orizzonte di un nuovo sentire, Conclusione. Contributo di Igor Scognamiglio: Evoluzione del principio femminile in tre film di Almodóvar, Conclusione

El principio femenino en Pedro Almodóvar. Un camino de educación para sentir

Over time in his movies, Pedro Almodóvar not only has explored female sensibility, but has showed that it can be defined, in the latest modernity, as an “avant-garde” in the ability to live feelings and move in the direction of a full expression of the potential of the human being. On the article, at first it’s exposed how the director from La Mancha has showed that the path to the liberation of desire goes through the subversion of roles and structured habits in the dominant culture. Then the audience is invited to follow its female characters in a new continent of feelings.Pedro Almodóvar en sus películas, a lo largo del tiempo, no sólo ha explorado la sensibilidad femenina, sino que ha demostrado que esta última puede definirse, en el Occidente de la última modernidad, como una “vanguardia” en la capacidad de vivir los sentimientos y de moverse hacia una plena expresión de las potencialidades del ser humano. En el  artículo  se expone primero cómo el director manchego mostró que el camino para la liberación del deseo pasa por la subversión de los papeles y hábitos estructurados en la cultura dominante. Luego se invita al público a seguir a sus personajes femeninos en un nuevo continente de los sentimientos

The feminine principle in Pedro Almodóvar. A path of education to feel

Pedro Almodóvar en sus películas, a lo largo del tiempo, no sólo ha explorado la sensibilidad femenina, sino que ha demostrado que esta última puede definirse en el Occidente de la última modernidad, como una “vanguardia” en la capacidad de vivir los sentimientos y de moverse hacia una plena expresión de las potencialidades del ser humano. En el artículo se expone primero cómo el director manchego mostró que el camino para la liberación del deseo pasa por la subversión de los papeles y hábitos estructurados en la cultura dominante. Luego se invita al público a seguir a sus personajes femeninos en un nuevo continente de los sentimientos.Over time, Pedro Almodóvar in his movies not only has explored female sensibility, but has showed that it can be defined, in the latest modernity, as an “avant-garde” in the ability to live feelings and move in the direction of a full expression of the potential of the human being. At first the manchigan director has showed that the path to the liberation of desire passes through the subversion of roles and habits structured in the dominant culture. Then he has invited the audience to follow its female characters in a new continent of feelings

User needs elicitation via analytic hierarchy process (AHP). A case study on a Computed Tomography (CT) scanner

Background: The rigorous elicitation of user needs is a crucial step for both medical device design and purchasing. However, user needs elicitation is often based on qualitative methods whose findings can be difficult to integrate into medical decision-making. This paper describes the application of AHP to elicit user needs for a new CT scanner for use in a public hospital. Methods: AHP was used to design a hierarchy of 12 needs for a new CT scanner, grouped into 4 homogenous categories, and to prepare a paper questionnaire to investigate the relative priorities of these. The questionnaire was completed by 5 senior clinicians working in a variety of clinical specialisations and departments in the same Italian public hospital. Results: Although safety and performance were considered the most important issues, user needs changed according to clinical scenario. For elective surgery, the five most important needs were: spatial resolution, processing software, radiation dose, patient monitoring, and contrast medium. For emergency, the top five most important needs were: patient monitoring, radiation dose, contrast medium control, speed run, spatial resolution. Conclusions: AHP effectively supported user need elicitation, helping to develop an analytic and intelligible framework of decision-making. User needs varied according to working scenario (elective versus emergency medicine) more than clinical specialization. This method should be considered by practitioners involved in decisions about new medical technology, whether that be during device design or before deciding whether to allocate budgets for new medical devices according to clinical functions or according to hospital department

User needs elicitation via analytic hierarchy process (AHP). A case study on a Computed Tomography (CT) scanner

Abstract Background The rigorous elicitation of user needs is a crucial step for both medical device design and purchasing. However, user needs elicitation is often based on qualitative methods whose findings can be difficult to integrate into medical decision-making. This paper describes the application of AHP to elicit user needs for a new CT scanner for use in a public hospital. Methods AHP was used to design a hierarchy of 12 needs for a new CT scanner, grouped into 4 homogenous categories, and to prepare a paper questionnaire to investigate the relative priorities of these. The questionnaire was completed by 5 senior clinicians working in a variety of clinical specialisations and departments in the same Italian public hospital. Results Although safety and performance were considered the most important issues, user needs changed according to clinical scenario. For elective surgery, the five most important needs were: spatial resolution, processing software, radiation dose, patient monitoring, and contrast medium. For emergency, the top five most important needs were: patient monitoring, radiation dose, contrast medium control, speed run, spatial resolution. Conclusions AHP effectively supported user need elicitation, helping to develop an analytic and intelligible framework of decision-making. User needs varied according to working scenario (elective versus emergency medicine) more than clinical specialization. This method should be considered by practitioners involved in decisions about new medical technology, whether that be during device design or before deciding whether to allocate budgets for new medical devices according to clinical functions or according to hospital department.</p

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition

Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that includes its binding to NME1, TGF-β activation, OTX2 upregulation, SNAIL (SNAI1) upregulation, and PTEN inhibition. The newly identified small molecule pyrimido-pyrimidine derivative AA7.1 enhances PRUNE1 degradation, inhibits this activation network, and augments PTEN expression. Both AA7.1 and a competitive permeable peptide that impairs PRUNE1/NME1 complex formation, impair tumour growth and metastatic dissemination in orthotopic xenograft models with a metastatic medulloblastoma group 3 cell line (D425-Med cells). Using whole exome sequencing technology in metastatic medulloblastoma primary tumour cells, we also define 23 common 'non-synonymous homozygous' deleterious gene variants as part of the protein molecular network of relevance for metastatic processes. This PRUNE1/TGF-β/OTX2/PTEN axis, together with the medulloblastoma-driver mutations, is of relevance for future rational and targeted therapies for metastatic medulloblastoma group 3.Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that includes its binding to NME1, TGF-β activation, OTX2 upregulation, SNAIL (SNAI1) upregulation, and PTEN inhibition. The newly identified small molecule pyrimido-pyrimidine derivative AA7.1 enhances PRUNE1 degradation, inhibits this activation network, and augments PTEN expression. Both AA7.1 and a competitive permeable peptide that impairs PRUNE1/NME1 complex formation, impair tumour growth and metastatic dissemination in orthotopic xenograft models with a metastatic medulloblastoma group 3 cell line (D425-Med cells). Using whole exome sequencing technology in metastatic medulloblastoma primary tumour cells, we also define 23 common 'non-synonymous homozygous' deleterious gene variants as part of the protein molecular network of relevance for metastatic processes. This PRUNE1/TGF-β/OTX2/PTEN axis, together with the medulloblastoma-driver mutations, is of relevance for future rational and targeted therapies for metastatic medulloblastoma group 3. 10.1093/brain/awy039-video1 awy039media1 574205353400